TABLE 3.

FICIs for antifungal plus immunosuppressant combinations against A. fumigatus isolates

Antifungal combinationFICIa (range) of drugs against isolates from:P valueb
Transplant recipients (n = 6)Nontransplant patients (n = 6)
Amphotericin B + FK5061.68 (1-2.5)1.64 (1-3)0.80
Amphotericin B + CsA2.12 (1.5-3)2.09 (1-3)0.80
Amphotericin B + rapamycin1.60 (1.25-2)1.65 (1.5-2)0.85
Voriconazole + FK5063.97 (2.5-6.1)3.39 (2.25-6.1)0.46
Voriconazole + CsA3.34 (2-4)3.21 (2.25-4.5)0.75
Voriconazole + rapamycin2.69 (2-5)3.06 (2-5)0.49
Caspofungin + FK5060.85 (0.57-1.5)1.05 (0.57-1.24)0.23
Caspofungin + CsA1.50 (1.06-3)1.16 (0.56-2)0.57
Caspofungin + rapamycin2 (N/Ac)2 (N/A)0.99
  • a Geometric mean.

  • b P values for the values for the isolates from transplant recipients and nontransplant patients.

  • c N/A, data unknown.