TABLE 3.

Resistance of P. aeruginosa isolates to both agents in potential combination regimensa

YrCefepimeImipenemPiperacillin-tazobactamAztreonam
CIPTOBAKCIPTOBAKCIPTOBAKCIPTOBAK
1993NANANA532NANANA744
1994NANANA656NANANA1188
1995NANANA633NANANA1055
1996NANANA643NANANA1066
1997NANANA9435221155
199810548527431465
19991510610648631696
2000168610638431776
200119119138595420108
200217116169574417117
P valueb<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001<0.00010.00020.013<0.0001<0.0001<0.0001
  • a AK, amikacin; CIP, ciprofloxacin; TOB, tobramycin; NA, not available. Data presented as percentages.

  • b P values representative of available resistance data over the 10-year period.