TABLE 1.

IC50s of 6-methylidene penem and tazobactam (TZB) molecules for isolated β-lactamases

InhibitorIC50 (nM) for:
TEM-1Imi-1CcrAAmpC
A1.1582605.4
B0.6202302.2
C1.4722402.1
D0.47.8664.8
E1.250141.5
F1.4561101.5
G3.1NDaND3.5
TZB100ND400,00084,000
  • a ND, not determined.