TABLE 4

Combinations of statins and C7S against T. gondii in vitro

Combination testedMean sum FICaSynergyb
Cerivastatin + C7S0.18 ± 0.09++
Pitavastatin + C7S0.25 ± 0.07++
Atorvastatin + C7S0.32 ± 0.11++
Lovastatin + C7S0.43 ± 0.12+
Simvastatin + C7S0.51 ± 0.26+−
Mevastatin + C7S0.54 ± 0.19+−
Atorvastatin + atovaquone0.55 ± 0.13+−
  • a Results are expressed as mean values ± SD from three independent experiments.

  • b ++, strong synergistic interaction (sum FIC < 40); +, synergy (sum FIC < 50); +−, very mild synergy, not a very strong interaction (sum FIC < 60).