TABLE 2.

Geometric-mean pharmacokinetics data following multiple daily doses of caspofungina

Dose (mg/day)StudyNo. of subjectsAUC0-24 (μg · h/ml)C1h (μg/ml)C24h (μg/ml)t1/2β (h) ± SDt1/2γ (h) ± SD
Day 1Day 14Day 14/day 1 ratioDay 21Day 21/day 1 ratioDay 1Day 14Day 14/day 1 ratioDay 21Day 21/day 1 ratioDay 1Day 14Day 14/day 1 ratioDay 21Day 21/day 1 ratio
15B519.66 (17.94, 21.55)24.37 (21.45, 27.69)1.24 (1.15, 1.33)2.47 (2.20, 2.78)2.79 (2.51, 3.10)1.13 (1.04, 1.23)0.29 (0.24, 0.34)0.38 (0.31, 0.47)1.31 (1.17, 1.46)8.60 ± 0.8940.90 ± 2.91b
35B541.18 (37.57, 45.14)54.90 (48.32, 62.38)1.33 (1.24, 1.43)5.22 (4.65, 5.88)5.97 (5.38, 6.63)1.14 (1.05, 1.24)0.59 (0.50, 0.70)0.92 (0.75, 1.13)1.56 (1.40, 1.74)9.51 ± 1.2146.73 ± 5.66
50D857.57 (51.85, 63.91)86.90 (76.06, 99.29)1.51 (1.43, 1.59)7.64 (7.02, 8.33)8.74 (7.92, 9.63)1.14 (1.07, 1.22)0.76 (0.60, 0.96)1.59 (1.30, 1.95)2.09 (1.82, 2.40)10.09 ± 1.5842.13 ± 10.38
70/50cD897.63 (87.94, 108.39)100.47 (87.93, 114.79)1.03 (0.98, 1.08)12.09 (11.10, 13.16)9.94 (9.02, 10.96)0.82 (0.77, 0.88)1.41 (1.12, 1.78)1.77 (1.45, 2.17)1.26 (1.09, 1.44)10.58 ± 1.1346.08 ± 8.18
70B696.01 (88.29, 104.40)144.27 (128.40, 162.10)1.50 (1.41, 1.60)12.31 (11.06, 13.70)15.42 (14.00, 16.97)1.25 (1.16, 1.35)1.33 (1.14, 1.56)2.61 (2.15, 3.15)1.96 (1.77, 2.17)10.70 ± 1.2250.16 ± 6.54
70C1093.47 (86.34, 101.20)129.61 (117.91, 142.47)1.39 (1.35, 1.43)137.29 (126.03, 149.55)1.47 (1.43, 1.51)12.14 (11.50, 12.81)14.03 (13.26, 14.86)1.16 (1.12, 1.19)14.26 (13.47, 15.10)1.17 (1.14, 1.21)1.30 (1.11, 1.51)2.37 (2.07, 2.72)1.83 (1.77, 1.89)2.57 (2.23, 2.96)1.98 (1.85, 2.12)11.16 ± 1.2045.50 ± 6.30
  • a Values in parentheses are 90% CIs.

  • b The number of t1/2γ obtained was 4 at this dose.

  • c 70 mg on day 1 followed by 50 mg daily on days 2 through 14.