TABLE 1.

Anti-influenza virus activities of T-705, GS 4071, amantadine, and ribavirin

Virus type and strainIC50 (μg/ml)a
T-705GS 4071AmantadineRibavirin
A (H1N1)
    PR/8/340.160.0039>507.7
    FM/1/470.200.00560.301.6
    NWS/330.0910.0020>5012
    Yamagata/120/860.120.00961.64.1
    Suita/1/890.0290.0025>508.7
A (H2N2)
    Kaizuka/2/650.0290.680.158.3
    Okuda/570.0130.000440.254.9
    Japan/305/570.300.000390.06213.8
    Takathuki/4/650.0480.000170.19Not tested
A (H3N2)
    Port Chalmers/1/730.460.00060Not tested5.8
    Aichi/2/680.0780.00300.634.3
    Ibaraki/1/900.300.000490.474.8
    Kitakyushu/159/930.480.00056>5020
B
    Nagasaki/1/870.0890.0063>5019
    Guandong/5/940.0530.031>501.2
    Mie/1/930.0390.015>504.6
C
    Taylor/1233/470.044>100Not testedNot tested
    Yamagata/3/960.057>100Not testedNot tested
    JJ/500.030>100Not testedNot tested
GS 4071-resistant virus A/PR/8/34b0.095c25cNot testedNot tested
  • a The Values are averages of results from two or three independent experiments.

  • b Isolated by passage in GS 4071 six times.

  • c The values are IC90s (the concentrations required to reduce the viral yield by 1 log10).