TABLE 5.

Rate of MRSA killing by cell wall-active agentsa

MRSA strain (EDP)CompoundTest conditionbMIC (μg/ml)Log10 reduction of CFU/ml at 6 h
A27223 (1)BMS-247243−NaCl22.3
+NaCl41.2
Vancomycin−NaCl0.51.2
+NaCl10.3
A27218 (10−7)BMS-247243−NaCl22.1
+NaCl21.5
Vancomycin−NaCl11.6
+NaCl10.8
A27217 (10−6)BMS-247243−NaCl11.8
+NaCl21.4
  • a Time-kill tests were performed in MHB with or without 2% NaCl and with 16 μg of the test compound per ml.

  • b −NaCl, without NaCl; +NaCl, with NaCl.