TABLE 4.

PBP 2a binding for BMS-247243 and other β-lactamsa

CompoundMIC (μg/ml)bPBP 2a IC50 (μg/ml)b
BMS-24724340.7
Methicillin>128>100
Cefuroxime>128>100
Cefotaxime>128>100
Cephalothin6480
Cephaloridine814
  • a PBP 1 to 3 Binding affinities for BMS-247243, <0.3 μg/ml.

  • b MICs and IC50 vs for S. aureus A27225.