TABLE 2.

Demographic and clinical response parameters for Vietnamese adults with uncomplicated falciparum malaria orally treated with artemisinin by a standard- or escalating-dose regimen

ParameterStandard dosingEscalating-dose dosingP value
Demographics
    Gender (no. of males, no. of females)28, 1225, 12>0.99
    Age (yr)a27.7 ± 10.228.1 ± 10.50.90
    Body wt (kg)a49.8 ± 6.148.8 ± 6.20.90
    Initial parasitemia (no. of parasites/μl of blood)
        Geometric mean8,2905,4080.90
        Range1,120-137,9201,012-208,320
Clinical response
    PCT50 (h)b10.8 ± 3.3 (9.7, 11.9)11.2 ± 5.2 (9.5, 13.9)0.85
    PCT (h)b34.1 ± 14.1 (29.6, 38.6)50.2c ± 23.4 (42.3, 58.0)<0.01
    PMRT (h)b7.3 ± 2.7 (6.5, 8.2)11.1 ± 7.0 (8.8, 13.4)<0.01
    PAUC (no. of parasites · h/μl of blood)d271,522 ± 353,430 (138,971)536,359c ± 1,724,730 (100,386)0.09
    FST (h)b24.8 ± 9.6 (21.7, 27.9)25.7 ± 15.9 (20.4, 31.0)0.60
  • a Values are means ± standard deviations.

  • b Values are means ± standard deviations (95% confidence intervals).

  • c Including the arbitrary value of 120 h for one patient.

  • d Values are means ± standard deviations (geometric means).