TABLE 2.

In vitro susceptibilities of 41 isolates of miscellaneous filamentous fungi to amphotericin B, itraconazole, and three investigational triazole antifungal agents

Organism (no. tested) and antifungal agentMIC (μg/ml)% Susceptible at MIC (μg/ml) of:
Range50%90%0.250.5124
Penicillium spp. (19)
    Amphotericin B0.12-211164295100100
    Itraconazole0.12-20.52166389100100
    Posaconazole0.03-10.2517489100100100
    Ravuconazole0.03-10.514274100100100
    Voriconazole0.06->80.512674959595
Fusarium spp. (7)
    Amphotericin B1-210086100100
    Itraconazole0.5->8>8014141414
    Posaconazole0.25->8>81429292943
    Ravuconazole0.5->8>8014292929
    Voriconazole0.5->88014292943
Rhizopus spp. (4)
    Amphotericin B0.5-11025100100100
    Itraconazole4->84000050
    Posaconazole1-42002575100
    Ravuconazole1-8100507575
    Voriconazole>8>800000
Mucor spp. (2)
    Amphotericin B0.50.50100100100100
    Itraconazole>8>800000
    Posaconazole>8>800000
    Ravuconazole>8>800000
    Voriconazole>8>800000
Paecilomyces spp. (2)
    Amphotericin B0.50.50100100100100
    Itraconazole0.25-0.50.2550100100100100
    Posaconazole0.12-0.50.1250100100100100
    Ravuconazole1-8100505050
    Voriconazole2-820005050
Trichosporon spp. (2)
    Amphotericin B0.06-80.065050505050
    Itraconazole8->8800000
    Posaconazole1->8100505050
    Ravuconazole0.12->80.125050505050
    Voriconazole0.05->80.5050505050
Acremonium sp. (1)
    Amphotericin B2000100100
    Itraconazole>800000
    Posaconazole100100100100
    Ravuconazole0.50100100100100
    Voriconazole0.50100100100100
Bipolaris sp. (1)
    Amphotericin B0.25100100100100100
    Itraconazole0.25100100100100100
    Posaconazole0.050100100100100
    Ravuconazole100100100100
    Voriconazole0.50100100100100
Chrysosporium sp. (1)
    Amphotericin B0.06100100100100100
    Itraconazole0.50100100100100
    Posaconazole0.12100100100100100
    Ravuconazole>800000
    Voriconazole>800000
Geotrichum sp. (1)
    Amphotericin B0.25100100100100100
    Itraconazole0.50100100100100
    Posaconazole0.25100100100100100
    Ravuconazole0.06100100100100100
    Voriconazole0.03100100100100100
Wangiella dermatitidis (1)
    Amphotericin B100100100100
    Itraconazole100100100100
    Posaconazole0.06100100100100100
    Ravuconazole100100100100
    Voriconazole0.12100100100100100