TABLE 1.

In vitro susceptibilities of 198 isolates of Aspergillus species to amphotericin B, itraconazole, and three investigational triazole antifungal agents

Organism (no. tested) and antifungal agentMIC (μg/ml)% Susceptible at MIC (μg/ml) of:
Range50%90%0.250.5124
A. fumigatus (114)
    Amphotericin B0.5-411029899100
    Itraconazole0.25-21222477100100
    Posaconazole0.03-10.250.58199100100100
    Ravuconazole0.25-40.50.516959899100
    Voriconazole0.12-40.250.588989999100
A. niger (22)
    Amphotericin B0.25-111946100100100
    Itraconazole0.5-2220936100100
    Posaconazole0.25-10.514182100100100
    Ravuconazole0.5-4120145096100
    Voriconazole0.25-20.51147396100100
A. flavus (13)
    Amphotericin B1-2120062100100
    Itraconazole0.25-10.51869100100100
    Posaconazole0.12-10.250.55492100100100
    Ravuconazole0.12-10.51862100100100
    Voriconazole0.06-10.512392100100100
A. versicolor (9)
    Amphotericin B1-210089100100
    Itraconazole0.5-2201133100100
    Posaconazole0.06-20.5336778100100
    Ravuconazole0.12-21114489100100
    Voriconazole0.25-20.5445689100100
A. terreus (8)
    Amphotericin B1-42002588100
    Itraconazole0.25-0.50.525100100100100
    Posaconazole0.06-0.250.12100100100100100
    Ravuconazole0.25-0.50.2550100100100100
    Voriconazole0.25-0.50.2575100100100100
Aspergillus spp. (32)
    Amphotericin B0.12-2123375100100
    Itraconazole0.5->812025729497
    Posaconazole0.06->80.2516381949494
    Ravuconazole0.12->80.513166919497
    Voriconazole0.12->80.2515078949497
All isolates (198)
    Amphotericin B0.12-412268999100
    Itraconazole0.25->812227729999
    Posaconazole0.03->80.250.57092989999
    Ravuconazole0.12->80.511778929999
    Voriconazole0.06->80.250.56790989999