TABLE 3.

Pharmacokinetic parameters for Vietnamese male and female adults with uncomplicated falciparum malaria orally treated with artemisinin by a standard- or escalating-dose regimena

Dosing regimen (dose [mg])CLs/F (liter/h)P value for CLs/Fbt1/2 hP value for t1/2bCmax/DcP value for Cmax/DbTmax (h)P value for TmaxbMRT (h)P value for MRTb
Mean ± SD95% CIdMean ± SD95% CIMean ± SD95% CIMean ± SD95% CIMean ± SD95% CI
Standard<0.010.99<0.010.140.98
    Day 1 (500)1,019 ± 633e783, 1,2551.3 ± 1.1e0.9, 1.7244 ± 202e162, 3112.9 ± 1.9e2.3, 3.84.2 ± 1.4e3.7, 4.8
    Day 5 (500)8,104 ± 7,837f5,971, 12,8951.4 ± 2.4f0.8, 1.753 ± 47f35, 712.6 ± 1.2f2.1, 3.04.4 ± 3.9f2.8, 5.8
Escalating<0.010.87<0.010.190.48
    Day 1 (100)2,019 ± 1,277f1,503, 2,5351.1 ± 0.7f0.8, 1.4185 ± 194e93, 2322.8 ± 1.5f2.4, 3.73.5 ± 1.1f3.2, 4.0
    Day 5 (500)7,160 ± 5,614f4,983, 9,3361.1 ± 0.8e0.8, 1.457 ± 43f37, 702.5 ± 1.0f2.1, 2.93.7 ± 1.3e3.3, 4.2
P values for D1, D5g<0.01, 0.790.40, 0.790.36, 0.79
  • a The overall level of significance was set at 0.05 (two tailed) in all analyses.

  • b P values for within-group differences on the first and last treatment days.

  • c Cmax/D, dose-adjusted observed maximal concentration.

  • d 95% CI, 95% confidence interval.

  • e n = 29 to 31.

  • f n = 26 to 28.

  • g D1 and D5, between-group differences on the first and last treatment days, respectively.