TABLE 4.

St and relative fitness of mutations investigated

MutationNo.dSt (±1 SE [10−2])aP valueCost per generation (%)Relative fitness (95% confidence interval)
RpsL 42 Arg9−0.98 ± 0.370.9898.23-99.74
rrn 1408Gb18−3.10 ± 0.74<0.013.0595.45-98.35
rrn 1408Gc13−2.88 ± 0.59<0.012.8495.96-98.28
rrn 2058Gb6−0.46 ± 0.290.120.4698.96-100.12
rrn 2058Gc3−1.40 ± 0.40<0.011.3997.81-99.39
rrn 2059Gb9−2.63 ± 0.83<0.012.6095.74-99.00
rrn 2059Gc6−2.47 ± 0.23<0.012.4497.08-98.99
  • a Estimated by direct competition against an equal density of the drug-susceptible parental strain.

  • b Spontaneous mutants.

  • c Recombinant mutants.

  • d Number of independent experiments.