TABLE 1.

Characteristics of study isolates

StrainOrigindMICa (μg/ml) of:agr groupDelta- hemolysin activitySource of infection (reference)Comments (references)
VANOXA
PC-3NY84II0HD gortex graft fistula (34)GISA
Mu50bJPN2>128II0Mediastinitis status post surgery congenital heart diseaseGISA; original MIC of vancomycin, 8 μg/ml (12, 13)
Mu3bJPN2>128II0LungHetero-GISA; original MIC of vancomycin, 3 μg/ml (12, 13)
HIP5836NJ8128II0Probable peritoneal dialysis catheter (34)GISA
A5940cMO44II0Porcine aortic valveHetero-GISA
A6298cMA4>128II0Hemodialysis gortex graft fistula; origin knee replacementHetero-GISA; + beta-hemolysin
A6222cMA8>128II0Suprarenal aortic graftGISA
A5937MO1128II+Porcine aortic valveMRSA related to A5940
A6300MA2>128II0Hemodialysis gortex graft fistula; origin knee replacementMRSA related to A6298; + beta-hemolysin
SA321>128I++MRSA
RN66071<0.25II++
RN6607-V2<0.25II++Derived from growth of RN6607 in vancomycin
RN91202<0.25agr::tetM0agr knockout derived from RN6607; + beta-hemolysin
RN9120-V4<0.25agr::tetM0Derived from growth of RN9120 in vancomycin
  • a VAN, vancomycin; OXA, oxacillin.

  • b Strain authenticity was confirmed by PFGE (data not shown).

  • c Previously unpublished strains with reduced vancomycin susceptibility: A5937 and A5940 are from the same patient isolated at different time points and are identical as determined by PFGE (Fig. 1), and A6300 and A6298 are from the same patient isolated at different time points and are identical as determined by PFGE (Fig. 1).

  • d NY, New York; JPN, Japan; NJ, New Jersey; MO, Missouri; MA, Massachusetts.