TABLE 1.

Erythromycin MICs (in micrograms/milliliter) and 23S rRNA sequence data for R6 populations following continuous culture in the absence or presence of antibiotica

Transformant populationPresence/absence of ERYDay 0MICDay 7MICDay 14MICDay 21MIC
23S rRNA gene no.23S rRNA gene no.23S rRNA gene no.23S rRNA gene no.
1234123412341234
TAMMMM>128HHHW>128WWWW0.03WWWW0.03
+MMMM>128MMMM128MMMM>128
TBMMMM>128MMMM>128MMMM>128MMMM>128
+MMMM>128MMMM>128MMMM>128
  • a M, fully mutated at loci 2057 and 2059 (2057AAG2059); H, heterogeneous at loci 2057 and 2059 (2057GAA2059 and 2057AAG2059); W, wild type at loci 2057 and 2059 (2057GAA2059).