TABLE 2.

In vitro activities of TMP, PMT, PNT, and sulfonamides against Aspergillus species in YNB

Species (n)In vitro activity (μg/ml) ofa:
TMPSMXSXTPMTDAPSSXSMTSDZSMPPNT
GMMFCGMMFCGMMFCGMMFCGMMFCGMMFCGMMFCGMMFCGMMFCGMMFC
A. fumigatus (20)>16>1619.3>32019.3>320>4>4>16>16>400>400105>50039.2>40059.4>400>128>128
A. flavus (10)>16>1664.9>32064.9>320>4>4>16>16>400>4001,000>500303.1>400114.8>400>128>128
A. niger (10)>16>1649.2>32074.6>3202.6>4>16>16>400>400>500>50081.2>40070.6>4004.92>128
A. nidulans (10)>16>1622.9>32016.2>3201.8>4>16>16214.3>40053.9>50024.3>40040.6>4000.46.5b
A. ustus (10)>16>16>320>320>320>320>4>4>16>16303.1>400>500>500>400>400373.2>4001.1128
A. terreus (10)>16>16226>320184>320>4>4>16>16>400>400>500>500>400>400400>4002.14>128
  • a GM, geometric mean of the MIC.

  • b GM range, 2 to 16 μg/ml. MFCs at which 50 and 90% of the isolates are tested, 8 and 16 μg/ml, respectively.