Parameter | Estimate | Bootstrap 95% CI^{a} | Shrinkage (%) |
---|---|---|---|

CL/F_{day 1}^{b} (liter/h) | 3.35 | 3.11–3.56 | |

ΔCL/F_{day 29} (%) | 14.3 | 6.0–25.8 | |

V/F^{b} (liter) | 43.2 | 41.5–44.7 | |

k
_{a}^{e} (h^{−1}) | 3.54 | 3.0–4.27 | |

MTT^{f} (h) | 0.542 | 0.47–0.61 | |

NN^{c} | 28 | 7–52 | |

F
^{d}
| 1 fixed | ||

Between-subject variability (%) | |||

CL | 16.3 | 11.0–20.0 | 12.8 |

F | 10.7 | 7.6–13.2 | 18.5 |

Between-occasion variability (%) | |||

CL | 13.3 | 10.0–15.4 | 31.5 |

F | 11.9 | 8.5–15.5 | 13.5 |

k_{a} | 84.0 | 79.7–97.5 | 30.3 |

MTT | 52.9 | 40.1–68.7 | 39.9 |

Error | |||

Additive (mg/liter) | 1.23 | 0.85–1.57 | |

Coefficient of variation (%) | 4.4 | 2.8–5.4 |

↵a CI, confidence interval.

↵b This parameter has been adjusted by allometric scaling, and the values reported refer to a subject with FFM of 42 kg (the median value of the cohort). The individual estimates for clearance and volume parameters were defined as CL

_{i}= θ_{CL}(FFM_{i}/42)^{0.75}·*e*^{(BSVCL + BOVCL)}and*V*= θ_{i}(FFM_{v}_{i}/42)^{1}, respectively. θ_{CL}is the typical values for clearance and θis the typical value for volume of distribution._{v}↵c NN, number of absorption transit compartments.

↵d

*F*, bioavailability.↵e

*k*, absorption rate constant._{a}↵f MTT, mean transit time.