TABLE 2.

Survival times for mice infected with three different zygomycete isolates and treated with amphotericin B at 4.5 mg/kg of body weight/day, itraconazole at 100 mg/kg/day, or terbinafine at 150 mg/kg/daya

GroupMedian survival time (days) and range for isolateb
R. microsporus AZN 1185A. corymbifera AZN 4095A. elegans AZN 1829
Control5 (4-8)3.5 (2-9)3 (3-6)
Amphotericin B15 (15)*15 (15)**15 (15)**
Itraconazole4 (3-6)10.5 (6-15)*15 (5-15)**
Terbinafine4 (4-5)3 (2-8)NDc
  • a Treatment was started 2 h after inoculation and given for 10 days.

  • b *, P < 0.01 (compared with controls); **, P < 0.001 (compared with controls).

  • c ND, not done.