TABLE 2.

Protein sequence alterations associated with resistancea

MutationResult for isolates whose complete gene was sequencedResult for isolates for which the hot spot III region was sequenced
4711358922
D116EHeterozyg.Heterozyg.Homozyg.
K128TWTHeterozyg.Homozyg.
K143RWTWTHomozyg.
E266DHomozyg.WTWT
V437IHeterozyg.WTWTWTHomozyg.WTWTHomozyg.
G448RWTWTWTWTWTHomozyg.WTWT
  • a Point mutations that resulted in amino acid changes identified by sequencing of ERG11 from the indicated isolates. WT, the amino acid at that position was wild type (no change occurred in either allele); Heterozyg., the amino acid at that position was mutated as indicated in one allele; Homozyg., the amino acid at that position was mutated as indicated in both alleles.