TABLE 1

Characteristics of patients with bloodstream infection caused by extended-spectrum-β-lactamase-producing Enterobacteriaceae according to therapy

Patient characteristicValue(s)
Empirical therapy cohort (n = 174)Definitive therapy cohort (n = 251)
Carbapenem; n = 126BLBLI; n = 48PCarbapenem; n = 234BLBLI; n = 17P
No. (%) of males76 (60.3)32 (66.6)0.55154 (65.8)7 (41.1)0.07
Median age in yrs (IQRa)50 (34–61)55 (40–63)0.1052 (36–63)57 (37–60)0.71
No. (%) of patients with:
    Acute leukemia70 (55.5)25 (52)0.99137 (58.5)9 (52.9)0.69
    Comorbidities18 (14.2)17 (35.4)0.00349 (20.9)5 (29.4)0.37
    Hematopoietic stem cell transplant49 (38.8)15 (31.25)0.4477 (32.9)6 (35.2)0.99
    Graft vs host disease13 (10.3)2 (4.1)0.7217 (7.2)2 (11.76)0.87
    Corticosteroid therapy73 (57.9)25 (52)0.58115 (49.1)11 (64.7)0.35
    Profound neutropenia (<100 neutrophils/mm3)17 (13.4)9 (18.7)0.4837 (15.8)3 (17.6)0.72
Median no. of days of previous neutropenia (IQR)6 (3–12)5.5 (4–9)0.656 (3–12)7.5 (5.7–9)0.68
No. (%) of patients with:
    Previous antibiotics (1 mo)107 (84.9)33 (68.7)0.01187 (79.9)12 (70.5)0.61
    Previous hospital admission (1 mo)90 (71.4)36 (75)0.67167 (71.3)9 (52.9)0.09
    Previous episode of BSI19 (15)6 (12.5)0.8434 (14.5)2 (11.7)0.99
    Concomitant infection25 (19.8)7 (14.5)0.5151 (21.7)4 (23.5)0.99
    MASCC index score < 2157 (45.2)22 (45.8)0.99102 (43.5)7 (41.1)0.63
    Complex bloodstream infection25 (19.8)14 (29.1)0.2648 (20.5)7 (41.1)0.064
    Septic shock at presentation36 (28.5)10 (20.8)0.3853 (22.6)2 (11.7)0.7
    Granulocyte colony-stimulating factor79 (62.7)23 (47.9)0.075129 (55.1)6 (35.2)0.14
    Active combination antibiotic therapy42 (33.3)12 (25)0.3722 (9.4)1 (5.8)0.99
    Adequate initial empirical antibiotic therapy 179 (76.5)15 (88.2)0.37
    Enterobacteriaceae species infection
        Escherichia coli91 (72.2)37 (77)0.77174 (74.3)14 (82.3)0.84
        Klebsiella pneumoniae31 (24.6)11 (22.9)54 (23)3 (17.6)
        Enterobacter cloacae1 (0.79)03 (1.2)0
        Klebsiella oxytoca3 (2.38)03 (1.2)0
  • a IQR, interquartile range.