TABLE 2.

ED50 and MIC ratios of cytotoxic to trypanocidal activities of proteasome inhibitorsa

CompoundED50 (HL-60)/ED50 (T. brucei)MIC (HL-60)/MIC (T. brucei)
AC-Leu-Leu-Nle-CHO102>1
AC-Leu-Leu-Met-CHO13>1
Z-Ile-Glu(OtBu)-Ala-Leu-CHO4192,500
Z-Leu-Leu-Leu-CHO13>25
Z-Leu-Leu-Phe-CHO0.814
Z-Leu-Leu-Tyr-COCHO4>1
Z-Leu-Leu-Leu-B(OH)23100
  • a ED50 and MIC ratios were calculated from ED50s and MICs shown in Table 1.