TABLE 4.

Microscopic examination results (presence of hyphae) for control and treated mice infected with R. microsporus A. corymbifera, and A. elegansa

Strain and group (no. of mice in group)No. of survivorsPercentage of positive results forb,d:
KidneySpleenLungLiverBrain
R. microsporus AZN 1185
    Control (20)0100903540100
    Amphotericin B (10)100***0***00*0***
    Itraconazole (10)010080020100
    Terbinafine (10)010090300*100
A. corymbifera AZN 4095
    Control (20)010050595
    Amphotericin B (10)100***00010***
    Itraconazole (10)480010078c
    Terbinafine (10)0100001080
A. elegans AZN 1829
    Control (20)010080359555
    Amphotericin B (10)100***0***00***0**
    Itraconazole (10)60***0***00***67c
  • a Amphotericin B was given at 4.5 mg/kg of body weight/day, itraconazole was given at 100 mg/kg/day, and terbinafine was given at 150 mg/kg/day. Treatment was started 2 h after inoculation and given for 10 days.

  • b Presence of hyphae.

  • c Brain from one mouse was not tested.

  • d *, P < 0.05 (compared with controls); **, P < 0.005 (compared with controls); ***, P < 0.0001 (compared with controls).