TABLE 1.

Association between protease mutations and resistance phenotype

Positions and mutationanPhenotype (fold resis- tance)% of strains resistant to:
IDVRTVSQVNFV
82, 54, 46, 90
    Mutation at ≥28R (≥8)631003867
    Mutation at none24S (<4)918510079
48, 90
    Mutation at ≥111R (≥8)10010010075
    Mutation at neither35S (<4)63558468
  • a Mutations: M46I, G48V, I54V or -T, V82A or -F, and L90M.