TABLE 1.

ED50s and MICs of proteasome inhibitors for bloodstream form T. brucei and human HL-60 cellsa

CompoundT. bruceiHL-60
ED50 (nM)MIC (nM)ED50 (nM)MIC (nM)
Ac-Leu-Leu-Nle-CHO45100,0004,600>100,000
Ac-Leu-Leu-Met-CHO1,600100,00020,000>100,000
Z-Ile-Glu(OtBu)-Ala- Leu-CHO0.0864036100,000
Z-Leu-Leu-Leu-CHO5.54,00073>100,000
Z-Leu-Leu-Phe-CHO1507,000120100,000
Z-Leu-Leu-Tyr-COCHO720100,0003,000>100,000
Z-Leu-Leu-Leu-B(OH)20.32101.11,000
  • a Values are the means of three independent experiments. The standard error never exceeded 30%.