TABLE 5.

Survival rates and times for mice infected with three different zygomycete isolates and treated with different doses of amphotericin Ba

Strain and groupbSurvival (%)Median survival time (days) and rangedPercentage of positive results for:
Kidney for:Brain for:
Hyphaec,dCultureHyphaec,dCulture
R. microsporus AZN 1185
    Control04 (4-6)100100100100
    AMB 210015 (15)§10020§100
    AMB 19015 (6-15)**10020§100
    AMB 0.510015 (15)§20§10030***100
A. corymbifera AZN 4095
    Control03 (2-6)10010010030
    AMB 210015 (15)§010¶0
    AMB 19015 (4-15)**3020§0
    AMB 0.59015 (4-15)**2010¶0
A. elegans AZN 1829
    Control03.5 (3-5)10040500
    AMB 210015 (15)§0100
    AMB 110015 (15)§00*0
    AMB 0.59015 (4-15)**10¶0100
  • a Ten mice in each group. Treatment was started 2 h after inoculation and given for 10 days.

  • b AMB 2, AMB 1, and AMB 0.5, amphotericin B given at 2, 1, and 0.5 mg/kg of body weight/day, respectively.

  • c Presence of hyphae detemined by microscopic examination.

  • d *, P < 0.05 (compared with controls); **, P < 0.01 (compared with controls); ***, P < 0.005 (compared with controls); §, P < 0.001 (compared with controls); ¶, P < 0.0001 (compared with controls).