TABLE 2.

Pharmacokinetics and pharmacodynamics of antibiotics used in the experiments

ParameterValue for druga
Imipenem (50 mg/kg)Sulbactam (30 mg/kg)Tobramycin (15 mg/kg)Rifampin (25 mg/kg)Colistin (125,000 U/kg)
Cmax (mg/liter)37.49 ± 1.3791.03 ± 0.0432.87 ± 5.4524.29 ± 10.2613.33 ± 4.61
t1/2 (h)0.190.180.375.440.52
AUC (mg · h/liter)11.9924.5711.54196.2211.96
IQ (Cmax/MIC)
    Strain A37.4945.510.263.0326.66
    Strain D4.6922.764.113.0326.66
    Strain E0.070.714.113.0326.66
t > MIC (h)
    Strain A1.151.109.713.05
    Strain D0.580.910.699.713.05
    Strain E000.699.713.05
  • a Dosage is given in parentheses after drug name.