TABLE 1.

Geometric mean IC50s, IC90s, and IC99, with 95% CIs, for mefloquine, quinine, chloroquine, and artesunate determined by the HRP2 drug susceptibility assay, a modified WHO schizont maturation assay, and the isotopic assaya

Drug and assay (n = 20)IC (nM [95% CI])
50%90%99%
MEF
    HRP265.32 (38.97-109.48)142.29 (91.73-220.71)189.73 (123.93-290.45)
    MORPH46.20 (28.43-75.08)95.23 (58.55-154.89)122.06 (75.29-197.88)
    RADIO70.03 (43.88-112.77)152.36 (100.49-231.00)206.83 (144.83-295.38)
QNN
    HRP2343.86 (239.93-492.80)903.13 (712.46-1,144.83)1,218.11 (952.20-1,558.29)
    MORPH364.84 (258.76-514.40)763.97 (571.30-1,021.61)950.98 (718.54-1,258.61)
    RADIO345.32 (260.43-457.89)847.99 (661.11-1,087.71)1,210.67 (970.68-1,509.98)
CHL
    HRP2217.39 (162.70-290.46)528.89 (395.00-708.15)739.08 (577.50-945.88)
    MORPH221.28 (160.68-304.74)421.93 (298.46-596.46)515.62 (367.13-724.17)
    RADIO117.98 (97.32-143.04)248.88 (206.11-300.53)313.51 (259.39-378.93)
ARS
    HRP22.06 (1.57-2.70)7.55 (5.00-11.40)15.60 (10.85-22.43)
    MORPH0.96 (0.82-1.13)1.48 (1.16-1.90)2.21 (1.58-3.08)
    RADIO2.82 (2.16-3.67)5.85 (4.77-7.16)7.45 (6.27-8.85)
  • a Abbreviations: MEF, mefloquine; QNN, quinine; CHL, chloroquine; ARS, artesunate; HRP2, HRP2 drug susceptibility assay; MORPH, a modified WHO schizont maturation assay; RADIO, isotopic assay.