TABLE 2.

Antifungal susceptibility of Candida isolates stratified by species and fluconazole susceptibility

Species (n)Antifungal agentFluconazole susceptibilitya
SS-DDRAll
nMIC50/MIC90%SnMIC50/MIC90%SnMIC50/MIC90%SnMIC50/MIC90%S
C. albicans (4,195)Fluconazole4,0540.25/0.51005616/32085>128/>12804,1950.25/0.597
Itraconazole0.03/012960.5/1111/>800.03/0.1293
Voriconazole0.007/0.015990.25/1931/>8570.007/0.0399
Ravuconazole0.007/0.015990.25/2890.25/>8730.007/0.0399
Amphotericin Bb0.5/1961/2851/2790.5/195
5FC0.5/1970.25/1960.25/1980.25/197
C. glabrata (949)Fluconazole5674/810030316/32078>64/>6409498/3260
Itraconazole0.5/161/208/>801/24
Voriconazole0.12/0.251000.5/1972/8130.25/192
Ravuconazole0.12/0.5990.5/2874/8110.25/289
Amphotericin B2/4462/4461/4572/447c
5FC0.12/0.12990.12/0.12980.12/0.12970.12/0.1299
C. parapsilosis (814)Fluconazole8030.5/2100816/NDd0264/ND08140.5/299
Itraconazole0.12/0.25550.5/ND00.25/ND00.12/0.254
Voriconazole0.03/0.061000.5/ND710.5/ND1000.03/0.0699
Ravuconazole0.03/0.121001/ND710.12/ND1000.03/0.1299
Amphotericin B2/4421/ND601/ND502/443c
5FC0.12/0.25990.12/ND1000.25/ND500.12/0.2599
C. tropicalis (597)Fluconazole5850.5/2100716/ND05>64/ND05970.5/298
Itraconazole0.12/0.5591/ND0>8/ND00.12/0.558
Voriconazole0.03/0.121001/ND50>8/ND00.06/0.1299
Ravuconazole0.03/0.12992/ND33>8/ND00.03/0.1298
Amphotericin B1/2571/ND501/ND501/257c
5FC0.5/1930.25/ND1000.5/ND1000.25/193
C. krusei (131)Fluconazole68/ND1006532/3206064/64013132/645
Itraconazole0.25/ND170.5/121/120.5/12
Voriconazole0.12/ND1000.25/0.51000.5/1980.5/0.599
Ravuconazole0.25/ND1000.25/0.5980.5/1980.5/0.598
Amphotericin B1/ND504/864/824/87c
5FC0.25/ND6716/32516/32216/326
C. dubliniensis (88)Fluconazole780.12/0.25100632/ND04>64/ND0880.25/1689
Itraconazole0.06/0.12910.12/ND500.5/ND00.06/0.2584
Voriconazole0.007/0.031000.25/ND1000.5/ND1000.007/0.03100
Ravuconazole0.007/0.031000.06/ND1000.06/ND1000.007/0.03100
Amphotericin B1/11000.12/ND1000.5/ND1000.25/0.5100
5FC0.06/0.061000.06/ND1000.06/ND1000.06/0.06100
C. guilliermondi (85)Fluconazole684/81001416/3202>64/ND0854/1681
Itraconazole0.5/171/104/ND01/17
Voriconazole0.12/0.251000.25/0.51002/ND00.12/0.2598
Ravuconazole0.25/0.5970.5/11004/ND00.25/198
Amphotericin B0.25/11000.5/11000.5/ND500.5/199
5FC0.12/0.51000.12/0.251000.06/ND1000.12/0.5100
C. lusitaniae (58)Fluconazole570.5/21001160580.5/298
Itraconazole0.12/0.2551200.12/0.2550
Voriconazole0.007/0.0151000.51000.007/0.015100
Ravuconazole0.015/0.06100200.015/0.0698
Amphotericin B0.5/1980.51000.5/198
5FC0.06/0.12910.061000.06/0.1293
  • a Fluconazole susceptibility categories are defined in the footnote to Table 1. n represents the number of isolates tested in each category. %S, percent susceptible: fluconazole MIC, ≤8 μg/ml; 5FC MIC, ≤4 μg/ml; itraconazole MIC, ≤0.12 μg/ml; all other MICs, ≤1 μg/ml.

  • b Amphotericin B MICs were determined by Etest.

  • c P < 0.001 compared to amphotericin B activity against C. albicans.

  • d ND, not determined (fewer than 10 isolates).