TABLE 3.

Results of lung bacterial countsa of A. baumannii

Therapeutic groupBacterial count (no. of mice) for:
Strain AStrain DStrain E
24 h48 h24 h48 h24 h48 h
Control10.55 ± 0.46b (15)10.70 ± 0.37b (15)10.58 ± 0.26b (15)10.80 ± 0.38b (15)10.51 ± 0.43b (15)10.78 ± 0.30b (15)
Imipenem6.49 ± 0.39c (4)5.32 ± 0.11c,d (4)8.72 ± 1.32c (4)6.32 ± 0.59c,d (4)10.3 ± 0.98 (4)11.02 ± 0.2 (4)
Sulbactam7.89 ± 1.08c (4)6.06 ± 0.58c,d (4)8.73 ± 1.07c (4)7.13 ± 1.95c (4)10.31 ± 0.2 (4)10.74 ± 0.20 (4)
Tobramycin10.69 ± 0.3 (4)10.72 ± 0.71 (4)10.37 ± 0.26 (4)7.35 ± 0.94c (4)7.88 ± 0.73c (4)6.62 ± 1.16c (4)
Rifampin7.77 ± 0.26c (4)6.89 ± 0.28c,e (4)8.8 ± 0.5c (4)7.18 ± 0.29c (4)7.64 ± 0.45c (4)5.63 ± 0.26c,e (4)
Colistin9.68 ± 0.99c (4)8.64 ± 0.66c (4)10.61 ± 0.26 (4)10.4 ± 1.09 (4)10.41 ± 0.41 (4)8.39 ± 1.22c (4)
  • a Lung bacterial counts are expressed in log10 of CFU/gram of lung tissue (mean of counts ± standard deviation).

  • b No significant differences were found between the three strains at 24 and 48 h.

  • c Differences were statistically significant compared with the control group (P < 0.05).

  • d Lung bacterial counts were significantly lower than those obtained with tobramycin, rifampin, and colistin.

  • e Lung bacterial counts were significantly lower than those obtained with colistin.