TABLE 1.

Resistance levels conferred by IMP-10 metallo-β-lactamasea

Strain and plasmidMIC (μg/ml)
CTXCAZAMPTICTIMPIPATMIPMMEM
P. aeruginosa
    PAI134>128>128>12812812844>128>128
    PAO4141, pMS455>128>128128646442864
    PAO4141, pMS364>128>128>1281281284232128
    PAO4141, pMS36040.5168811<0.50.5
    PAO414140.5168811<0.50.5
E. coli
    K-12 χ1037, pMS364641281632321<0.518
    K-12 χ1037, pMS360<0.5<0.58221<0.5<0.5<0.5
    K-12 χ1037<0.5<0.54221<0.5<0.5<0.5
  • a pMS455, plasmid-bearing blaIMP-10 gene; pMS364, recombinant plasmid-bearing blaIMP-10 gene; pMS360, vector plasmid. Abbreviations: CTX, cefotaxime; CAZ, ceftazidime; AMP, ampicillin; TIC, ticarcillin; TIM, ticarcillin-clavulanic acid; PIP, piperacilin; ATM, aztreonam; IPM, imipenem; MEM, meropenem.