TABLE 3.

Cross-resistance among approved and investigational triazoles

SpeciesAntifungal agentFluconazole/itraconazole susceptibility categoryanbCumulative % inhibited at MIC (μg/ml) of:
0.120.250.51248
C. albicans VoriconazoleRR3702.710.818.9c37.840.540.5
RS382.626.355.394.7c100
RavuconazoleRR3212.518.825.040.6c43.846.946.9
RS3850.089.597.4100c
C. glabrata VoriconazoleRR7000011.455.778.697.1
RS100100
RavuconazoleRR640009.442.271.992.2
RS1000100
C. krusei VoriconazoleRR39015.479.5100d
RS19026.389.594.7d94.7100
RavuconazoleRR35017.188.6100d
RS18033.388.994.4d94.4100
  • a R/R, fluconazole MIC of ≥64 μg/ml and itraconazole MIC of ≥1 μg/ml; RS, fluconazole MIC of ≥64 μg/ml and itraconazole MIC of ≤0.12 μg/ml.

  • b n, number of isolates tested in each category.

  • c P < 0.001 for difference in percent inhibited in RR versus RS.

  • d P > 0.05 for difference in percent inhibited in RR versus RS.