TABLE 1.

Percent susceptible, intermediate, and resistant (CLSI breakpoints) for doripenem versus P. aeruginosa and B. cepaciaa

OrganismAntimicrobialMIC50MIC90MinimumMaximumGeometric meanMode% S% I% R
All strains (n = 194)Doripenem0.2580.252560.590.25NANANA
Imipenem1160.252561.37183.004.6012.40
Levofloxacin180.251281.430.569.1010.8020.10
Piperacillin81280.25>5129.434SSSSSS
Ceftazidime2160.25>5122.98288.703.607.70
Aztreonam8640.25>5127.19866.012.4021.60
Tobramycin1640.25>5121.780.578.901.0020.10
Cefepime4320.252564.1278.909.8011.30
B. cepacia (n = 34)
Doripenem280.251282.358NANANA
Imipenem4160.251283.691650.0020.6029.40
Levofloxacin180.2581.20.2576.5011.8011.80
Piperacillin321282>51219.22241.2038.2020.60
Ceftazidime4160.25>5122.83482.4014.702.90
Aztreonam322560.2551221.726429.4014.7055.90
Tobramycin641280.2525618.456423.500.0076.50
Cefepime161280.252568.680.2547.1014.7038.20
P. aeruginosa (CF isolates; n = 82)
Doripenem0.2520.252560.520.25NANANA
Imipenem1160.252561.28186.601.2012.20
Levofloxacin1160.251281.750.563.4011.0025.60
Piperacillin82560.25>51210.85486.60NA13.40
Ceftazidime2320.252563.47284.102.4013.40
Aztreonam8640.25>5127.8863.4014.6022.00
Tobramycin0.580.255121.040.589.002.408.50
Cefepime2160.25643.52284.107.308.50
P. aeruginosa (non-CF isolates; n = 78)
Doripenem0.2510.25160.360.25NANANA
Imipenem120.25320.95193.601.305.10
Levofloxacin180.25641.250.571.8010.3017.90
Piperacillin8160.255125.97496.20NA3.80
Ceftazidime280.25642.61296.200.003.80
Aztreonam8160.25644.07884.609.006.40
Tobramycin120.25>5120.970.592.300.007.70
Cefepime2160.25323.47287.2010.302.60
  • a Abbreviations: S, susceptible; I, intermediate; R, resistant; NA, not applicable (no approved ranges); SS, species specific. MIC50, MIC90, minimum, maximum, geometric mean, and mode are all in micrograms per milliliter.