TABLE 3.

Posaconazole pharmacokinetic parameters on day 10

Parameter (unit)aValue [mean (% coefficient of variation)]
Group 1 (400 mg b.i.d.) (n = 24)Group 2 (600 mg b.i.d.) (n = 19)Group 3 (800 mg q.d.) (n = 18)
C max (ng/ml)851 (82)579 (71)361 (74)
C min (ng/ml)640 (98)388 (64)252 (100)
C av (ng/ml)723 (86)490 (71)259 (72)
C av, least square (ng/ml)523333184
T max (h)b3.0 (0, 12.5)3.83 (0, 10)4.04 (2.42, 12.5)
AUCτ (ng · h/ml)8,619 (86)5,823 (71)6,199 (71)
NAUC (ng · h/ml)c8,619 (86)3,882 (71)3,099 (71)
V/F (liters)2,447 (421)4,984 (919)5,061 (903)
CL/F (liters/h)283 (354)179 (82)215 (81)
T 1/2 (h)11.9 (3)12.0 (3)24 (2)
  • a C min, Trough plasma concentration; T1/2, half-life.

  • b Median (minimum, maximum).

  • c P value for log-transformed NAUC: 400 mg b.i.d. versus 600 mg b.i.d., P = 0.0004; 400 mg b.i.d. versus 800 mg q.d., P < 0.0001; 600 mg b.i.d. versus 800 mg q.d., P = 0.447.