TABLE 2.

Posaconazole pharmacokinetic parameters on day 3

Parameter (units)Value [mean (% coefficient of variation)]
Group 1 (200 mg q.i.d.) (n = 24)Group 2 (400 mg q.i.d.) (n = 21)Group 3 (800 mg b.i.d.) (n = 24)
Cmax (ng/ml)539 (82)531 (71)417 (60)
Cav (ng/ml)447 (84)423 (70)340 (63)
Tmaxa (h)2.65 (0, 11.8)5.78 (2, 12.4)4.21 (0, 11.9)
AUC(0-12) (ng · h/ml)5,314 (83)5,075 (71)4,035 (63)
  • a Median (minimum, maximum).