TABLE 1

Characteristics of patients with bacteremia due to colistin-resistant Klebsiella pneumoniae with high-level meropenem resistance receiving monotherapy or combination therapyd

VariableMonotherapy patients (n = 32)Combination therapy patients (n = 72)P value
Male, n (%)a14 (43.8)43 (59.7)0.13
Median age (yr) (IQR)c72 (78–61.25)62 (74.25–47)0.17
Comorbidities
    Chronic renal disease, n (%)a7 (21.9)20 (27.8)0.53
    Diabetes mellitus, n (%)a16 (50)20 (27.8)0.03
    Chronic obstructive pulmonary disease, n (%)a4 (12.5)11 (15.3)0.7
    Active solid tumor, n (%)a8 (25)22 (30.6)0.4
    Transplant, n (%)b2 (6.2)9 (12.5)0.50
Median Charlson index (IQR)c6 (7–2.5)3 (6–2)0.5
Admission from a care facility, n (%)b3 (9.4)7 (9.7)0.9
Prior known colonization, n (%)a8 (25)23 (31.9)0.5
Admission in previous 3 mo, n (%)a18 (56.3)29 (40.3)0.13
Surgery in previous week, n (%)a10 (31.3)26 (36.1)0.63
Invasive procedures in previous wka
    Central venous catheter, n (%)19 (59.4)53 (73.6)0.15
    Urinary catheter, n (%)26 (81.3)63 (87.5)0.4
    Mechanical ventilation, n (%)10 (31.3)40 (56.3)0.02
Admission warda0.01
    Medical, n (%)9 (28.1)20 (27.8)
    Surgical, n (%)11 (34.4)8 (11.1)
    Critical care, n (%)12 (37.5)44 (61.1)
Renal failure at time of diagnosis, n (%)a11 (34.4)33 (45.8)0.28
Source of infectiona0.12
    Pneumonia, n (%)8 (25)31 (43.1)
    Primary bacteremia, n (%)16 (50)22 (30.6)
    Urinary tract infection, n (%)8 (25)19 (26.4)
Median length of hospitalization (days) during follow-up (IQR)c16.5 (14.25–22.75)17 (12–24)0.92
Septic shock, n (%)a8 (25)40 (55.6)0.004
Median Pitt score (IQR)c3 (5–2)4 (5–2)0.30
Appropriate empirical therapy, n (%)a11 (34.4)44 (61.1)0.01
Mortality at 30 days of follow-up, n (%)a14 (43.8)18 (25)0.05
  • a P values were determined using Pearson's χ2 test.

  • b P values were determined using Fisher's exact test.

  • c P values were determined using the Mann-Whitney test.

  • d Abbreviations: IQR, interquartile range; HR, hazard ratio; n (%), number and percentage of patients.