TABLE 1.

NRTI susceptibilities for recombinant HIV

NRTIIC50a (μM) for:Fold change
HXB2D (wild type)Mutantb
Tenofovir3.0 ± 0.27.2 ± 1.12.4
AZT0.18 ± 0.024.4 ± 1.4024.0
d4T8.0 ± 0.411.8 ± 1.51.5
3TC2.2 ± 0.48.4 ± 1.23.8
ddC3.8 ± 0.56.0 ± 0.51.6
ddI4.0 ± 0.55.8 ± 0.51.5
Abacavir0.3 ± 0.030.7 ± 0.082.4
DXG1.9 ± 0.22.7 ± 0.61.4
  • a Values are averages from three to eight experiments ± standard errors. IC50, 50% inhibitory concentration.

  • b Mutant with D67N, K70R, and T215Y mutations.