TABLE 3.

Mutagenic action of sublethal concentrations of MTZ, NTZ, and furazolidone on Mtzs and Mtzr H. pylori

Drug concn (μg/ml)Mutation frequency (no. Rifr/108)
MetronidazoleNitazoxanideFurazolidone
WT (EOP)ardxA (EOP)WT (EOP)rdxA (EOP)WT (EOP)rdxA (EOP)
012 (1)8 (1)2.27 (1)6.10 (1)1.0 (1)4.35 (1)
0.25NTbNT1.27 (1)NT2.64 (0.1)16.43 (1)
0.5NTNT1.50 (1)2.94 (1)6.90 (0.1)64.91 (0.1)
1.014 (1)5 (1)1.41 (0.5)4.46 (1)0 (10−3)0
2.069 (10−2)10 (1)0.97 (0.1)2.47 (1)NTNT
3.0144 (10−2)5 (1)NTNTNTNT
5.00 (0)12 (1)0 (10−5)5.26 (0.5)NTNT
10.0NTNTNT0 (10−8)NTNT
25.0NT213 (10−2)NTNTNTNT
  • a Strains used were 26695 and the rdxA mutant. 0, insufficient survivors from which to calculate a mutation frequency. The data represent the means of three determinations each from two independent experiments. WT, wild type.

  • b NT, not tested.