TABLE 2

Susceptibilities of E. coli strains to antibiotics that are substrates of the AcrAB-TolC efflux pump

AntibioticMIC (μg/ml) for E. coli strain
BW25113BW25113ΔtolC::kanBW25113ΔacrA::kanBW25113 + 1 μg/ml SPR741ATCC 25922ATCC 25922 + 1 μg/ml SPR741
Clarithromycin>320.510.25320.125
Fusidic acid51214<8>1284
Linezolid>128886425632
Mupirocin1280.512648
Retapamulin80.1250.1250.0680.06