TABLE 1.

Ciprofloxacin and tobramycin PK/PD parameters obtained in the mouse model of lung infection by P. aeruginosa strains PAO1 and PAOΔmutS

TreatmentDose (mg/kg)Dosing interval (h)fCmax (mg/liter)ft1/2 (h)fAUC (mg · h/liter)MICa (μg/ml)fAUC/MICa ratiofCmax/MICa ratio
Ciprofloxacin2065.751.3048.160.12538560
Tobramycin10619.070.5542.9614319
  • a Ciprofloxacin and tobramycin MICs determined by Etest were identical for PAO1 and PAOΔmutS, and therefore, the same PK/PD parameters (fAUC/MIC and fCmax/MIC) were obtained for both strains.