TABLE 1

MIC-2 for white and opaque cells from two strain backgrounds exposed to 27 antifungal agents in SD+aa+Uri at 25°C

Class and drugSC5314WO-1
White MIC-2 (μg/ml [μM])Opaque MIC-2 (μg/ml [μM])Opaque MIC-2/white MIC-2White MIC-2 (μg/ml [μM])Opaque MIC-2 (μg/ml [μM])Opaque MIC-2/white MIC-2
Echinocandin
    Anidulafungin0.74 (0.65)0.45 (0.39)0.600.06 (0.05)0.03 (0.02)0.50
    Caspofungin0.50 (0.41)1.00 (0.82)2.000.13 (0.11)0.25 (0.21)2.00
    Micafungin0.50 (0.39)0.25 (0.20)0.500.12 (0.10)0.12 (0.10)1.00
Imidazole
    Bifonazole15.52 (50.00)7.76 (25.00)0.505.17 (16.67)7.76 (25.00)1.50
    Butoconazole0.02 (0.05)0.02 (0.05)1.000.01 (0.03)0.01 (0.03)1.00
    Clotrimazole0.13 (0.39)0.13 (0.39)1.000.07 (0.20)0.07 (0.20)1.00
    Econazole nitrate0.17 (0.39)0.17 (0.39)1.000.07 (0.16)0.06 (0.13)0.80
    Ketoconazole0.21 (0.39)0.21 (0.39)1.000.10 (0.20)0.10 (0.20)1.00
    Miconazole nitrate0.10 (0.20)0.05 (0.10)0.500.02 (0.05)0.02 (0.05)1.00
    Oxiconazole Nitrate0.19 (0.39)0.19 (0.39)1.000.10 (0.20)0.10 (0.20)1.00
    Sulconazole nitrate0.18 (0.39)0.18 (0.39)1.000.18 (0.39)0.18 (0.39)1.00
    Tioconazole0.03 (0.08)0.02 (0.05)0.600.02 (0.04)0.02 (0.05)1.20
Thiazole
    Abafungin4.73 (12.50)9.46 (25.00)2.000.30 (0.78)0.20 (0.52)0.67
Triazole
    Fluconazole1.56 (5.09)1.56 (5.09)1.000.78 (2.55)0.78 (2.55)1.00
    Itraconazole0.07 (0.10)0.07 (0.10)1.000.04 (0.05)0.04 (0.05)1.00
    Terconazole1.66 (3.13)1.66 (3.13)1.001.66 (3.13)1.66 (3.13)1.00
    Voriconazole0.02 (0.05)0.01 (0.03)0.500.01 (0.03)0.01 (0.03)1.00
Polyene
    Amphotericin B16.00 (17.31)10.67 (11.54)0.678.00 (8.66)8.00 (8.66)1.00
    Candicidin2.31 (2.08)3.47 (3.13)1.500.87 (0.78)0.87 (0.78)1.00
    Natamycin5.55 (8.33)4.16 (6.25)0.752.77 (4.17)2.08 (3.13)0.75
    Nystatin3.86 (4.17)2.89 (3.13)0.751.45 (1.56)2.41 (2.60)1.67
Squalene epoxidase inhibitor
    Terbinafine hydrochloride21.86 (66.67)8.20 (25.00)0.3821.86 (66.67)5.47 (16.67)0.25
    Amorolfine hydrochloride0.55 (1.56)0.55 (1.56)1.000.03 (0.10)0.03 (0.10)1.00
Other
    Ciclopirox olamine1.30 (6.25)1.30 (6.25)1.001.30 (6.25)1.30 (6.25)1.00
    Flucytosine>12.91 (100)>12.91 (100)NAa>12.91 (100)>12.91 (100)NA
    Griseofulvin>35.28 (100)>35.28 (100)NA>35.28 (100)>35.28 (100)NA
    Tolnaftate>30.74 (100)>30.74 (100)NA>30.74 (100)>30.74 (100)NA
  • a NA, not applicable