TABLE 8.

Cytotoxicity of benzimidazole ribosides and GCV to primary human bone marrow progenitor cellsa

Test compoundMean IC50 (μM) ± SEM
CFU-GMBFU-ENo. of determinations (no. of donors)
1263W9490 ± 488 ± 44 (4)
BDCRB110 ± 1890 ± 109 (9)
GCV15 ± 339 ± 1018 (15)
  • a Data for 1263W94 were previously reported by Chan et al. (5). CFU-GM, CFU of granulocytes-macrophages; BFU-E, burst-forming unit-erythroid.