TABLE 1.

Mean times of survival in temporarily immunosuppressed guinea pigs

Group (dose [mg/kg/day])aMortality (no. of animals that died/total no. of animals tested) [% of total])Mean survival time (days)b
Mean ± SERange
Control12/12 (100)4.5 ± 0.293-6
Caspofungin
    2.56/12 (50)c6.83 ± 0.37c5-8
    14/12 (33)c7.33 ± 0.31c5-8
Caspofungin (2.5) + voriconazole (5)0/12 (0)c8c8
Caspofungin (1) + voriconazole (5)0/12 (0)c8c8
Voriconazole (5)0/12 (0)c8c8
Amphotericin B3/12 (25)c7.08 ± 0.50c3-8
  • a There were 12 animals in each group.

  • b Time of survival from day of challenge with A. fumigatus.

  • c P < 0.0025 compared to controls.