TABLE 1.

Sensitivity of HCMV strain AD169 to benzimidazole ribosides and GCV in MRC-5 lung fibroblast cells

Test compoundMean IC50 (μM) ± SEMa as determined by:
NameBenzimidazole 2-substituentRibose configurationDNA hybridizationPlaque reductionYield reduction
1263W942-Isopropylaminol0.12 ± 0.01 (71)0.54 ± 0.05 (10)0.06 ± 0.018 (4)
3322W932-Isopropylaminod2.3 ± 0.5 (3)7.5 (1)1.3 ± 0.3
3858U922-Bromol0.9 ± 0.2 (5)1.3 ± 0.7 (3)0.5 ± 0.06
BDCRB2-Bromod0.54 ± 0.08 (20)0.31 ± 0.06 (6)0.018 ± 0.001
GCVNAbAcyclic0.53 ± 0.04 (117)6.3 ± 0.7 (6)0.30 ± 0.15 (2)
  • a The number of experiments is shown in parentheses.

  • b NA, not applicable.