TABLE 2.

Results of semiquantitative cultures of organs from guinea pigs treated with antifungal agents beginning 24 h after challenge and killed 96 h after completion of therapy

Group (dose [mg/kg/day])aColony count (mean ± SE log10CFU/g of tissue)
LiverLungKidneyBrain
Control3.32 ± 0.200.90 ± 0.223.11 ± 0.193.03 ± 0.23
Caspofungin
    2.53.19 ± 0.450.42 ± 0.131.64 ± 0.31b2.97 ± 0.40
    11.93 ± 0.48b0.56 ± 0.231.42 ± 0.39b1.47 ± 0.45
Caspofungin (2.5) + voriconazole (5)0.32 ± 0.20b0.11 ± 0.08b0.34 ± 0.19b0.13 ± 0.11b
Caspofungin (1) + voriconazole (5)0.08 ± 0.04b0.05 ± 0.04b0.13 ± 0.11b0.19 ± 0.20b
Voriconazole (5)0.35 ± 0.19b0.30 ± 0.070.58 ± 0.19b0.13 ± 0.09b
Amphotericin B1.22 ± 0.37b0.38 ± 0.170.98 ± 0.32b0.87 ± 0.44b
  • a There were 12 animals in each group.

  • b P < 0.0025 compared to controls.