TABLE 2.

Demographics of quinolone-nonsusceptible pneumococcal strains, their susceptibilities, detected mutations, and effluxa

StrainCityHospitalAge (yr)PFGE typeSero- typeMIC (μg/ml)bAmino acid change(s)
PeniAmox-ClavEryCiproLevoGemiGatiMoxiGyrAGyrBParCParE
2527ZagrebUniversity Hospital for Lung Diseases63A23F4.02.00.01616160.1254.02.0S81YS79FI460V
2529ZagrebUniversity Hospital for Lung Diseases20A23F4.02.00.01616160.254.04.0S81YS79FI460V
2536ZagrebUniversity Hospital for Lung Diseases41A23F2.02.00.01616160.1254.02.0S81YS79FI460V
2538ZagrebUniversity Hospital for Lung Diseases68A23F2.02.00.0168.0160.1254.02.0S81YS79FI460V
2542ZagrebUniversity Hospital for Lung Diseases64A23F4.02.00.01616160.254.02.0S81YS79FI460V
4026VarazdinPublic Health Institute44A23F2.02.00.016>32320.58.02.0S81YS79FI460V
2578CakovecPublic Health Institute7523F2.01.0≤0.0088.0160.1254.04.0S81YS79FI460V
4151ZagrebClinical Hospital Center Zagreb53142.02.00.038.02.00.1250.50.25S79FI460V
4205ZagrebUniversity Hospital of Infectious Diseases35B2NT0.030.030.038.04.00.060.50.25D83N
4214SplitPublic Health Institute59BNT0.030.030.034.08.00.1250.50.25I460V
4222SplitPublic Health Institute33110.030.030.034.08.00.060.50.25I460V
4227ZagrebUniversity Hospital of Infectious Diseases21B92.04.00.034.04.00.060.50.25K137NI460V
4229ZagrebSveti Duh General Hospital17150.50.25>644.04.00.060.50.25I460V
4329SplitUniversity Hospital Split62NT0.0160.0160.0164.04.00.1250.50.5K137N
4838ZagrebPublic Health Laboratory73B1110.030.030.038.04.00.061.00.5I460V
4912ZagrebUniversity Hospital Sestre Milosrdnice58B1110.030.060.034.04.00.061.00.5I460V
4941SplitUniversity Hospital Split18B394.02.00.064.04.00.060.50.25S79F, K137NI460V
4943ZagrebUniversity Hospital Sestre Milosrdnice53110.0160.0160.064.04.00.060.50.25N91D
4945SplitUniversity Hospital Split67B1110.030.060.038.04.00.061.00.5I460V
4967CakovecPublic Health Institute71B142.02.04.04.04.00.030.50.25I460V
4984CakovecPublic Health Institute589≤0.0080.0160.034.04.00.060.50.25
  • a Quinolone nonsusceptibility is defined by a ciprofloxacin MIC of ≥4 μg/ml. Abbreviations: PFGE, pulsed-field gel electrophoresis; Peni, penicillin; Amox-Clav, amoxicillin-clavulanic acid; Ery, erythromycin; Cipro, ciprofloxacin; Levo, levofloxacin; Gemi, gemifloxacin; Gati, gatifloxacin; Maxi, moxifloxacin; NT, nontypeable.

  • b Boldface values indicate the presence of an efflux mechanism.