TABLE 2.

Susceptibility of HCMV clinical isolates to 1263W94 and GCVa

Virus strainMean IC50 (μM) as determined by:
DNA hybridization assayPlaque reduction assay
1263W94GCV1263W94GCV
AD1690.040.400.974.30
C83010.040.250.121.10
C85010.101.000.341.00
C89100.120.700.191.40
C92070.030.150.446.70
C83030.090.800.540.80
C83020.100.300.162.70
C88030.130.700.213.40
C89120.040.500.212.60
C90030.121.100.561.00
C92130.040.400.407.00
  • a Assays were performed with HCMV-infected MRC-5 lung fibroblast cells. Values represent the average of two independent determinations. The standard error of the mean was <30% of the value shown in all assays.