TABLE 1.

Main pharmacokinetic variables calculated for the study populationa

Subjects and target siteAUCtissue/AUCplasmaAUC60-360min (mg/liter · h)Cmax (mg/liter)
Diabetic0.44 (0.08-2.02)
    Plasma184 (157-215)37.7 (35-45)
    Tissue18 (3.4-68)5.1 (0.87-15.5)
Nondiabetic1.45 (0.35-3.72)
    Plasma199 (160-206)40 (33-42)
    Tissue57.3 (14-157)12 (4-38)
  • a AUC, area under the concentration versus time curve; Cmax, maximum concentration of vancomycin. The values are presented as medians and ranges.