TABLE 5.

Summary of pharmacokinetic measures for isoniazid, pyrazinamide, and ethambutol

Drug and parameter2-h level (mg · liter−1)Tmax (h)Cmax (mg · liter−1)t1/2 (h)AUC0-8 (mg · h · liter−1)AUC0-∞ (mg · h · liter−1)
Isoniazid
    No. of patients142142142141141141
    Median5.01.56.52.825.032.5
    Interquartile range3.6-7.11.0-2.54.9-8.72.1-3.518.9-32.822.5-42.4
    Minimum-maximum0.4-13.60.5-4.00.5-15.01.0-8.41.7-64.03.5-87.2
Pyrazinamide
    No. of patients142142142141141141
    Median49.62.052.75.9288.4499.7
    Interquartile range41.1-56.41.1-2.546.0-61.44.9-7.1245.7-335.4406.2-632.3
    Minimum-maximum1.3-86.60.5-4.11.5-91.82.7-12.99.0-510.218.7-1,246.8
Ethambutol
    No. of patients127129129123129123
    Median3.13.05.02.619.924.9
    Interquartile range2.2-4.42.0-3.44.1-6.32.1-3.116.3-24.219.2-30.8
    Minimum-maximum0.8-9.81.0-6.10.2-10.41.1-8.10.2-45.26.9-54.0