TABLE 4.

Multiple linear regression models describing the AUC0-8 for rifampin, isoniazid, pyrazinamide, and ethambutol and β coefficients (95% confidence intervals) for associations between AUC0-8 and the covariate factors in univariate linear regression analyses

Parameterβ Coefficient (95% confidence interval) describing the AUC0-8s for the following drugs with the indicated regression modela:
Rifampin (21.5 [15.3-31.7])eIsoniazid (25.0 [18.9-32.9])Pyrazinamide (288.4 [245.7-335.4])Ethambutol (19.9 [16.3-24.2])
Multivariate (nb = 81)UnivariateMultivariate (nb = 133)UnivariateMultivariate (nb = 137)UnivariateMultivariate (nb = 125)Univariate
Male sex−8.7 (−13.7 to −3.7)−5.9 (−11.6 to −0.2)−5.7 (−8.9 to −2.5)−4.6 (−8.2 to −1.0)NS+2.4 (0.4 to 4.5)+2.1 (−0.1 to 4.4)
Age (yr)NSc+0.1 (0.0 to 0.3)+0.2 (0.0 to 0.3)NS+0.1 (0.0 to 0.2)+0.1 (0.0 to 0.2)
RetreatmentNSNSNS−3.5 (−5.8 to −1.3)−1.6 (−4.0 to 0.9)
HIV infection−8.3 (−16.7 to 0.0)−3.6 (−13.1 to 6.0)NSNS−5.5 (−9.1 to −1.9)−4.5 (−8.3 to −0.7)
FDC formulation−8.4 (−13.9 to −2.8)−5.6 (−11.8 to 0.6)−6.9 (−10.7 to −3.1)−5.5 (−10.0 to −1.0)d
Dose (mg/kg)+2.5 (0.9 to 4.1)+2.9 (1.2 to 4.7)+1.5 (0.2 to 2.7)+1.8 (0.4 to 3.2)+7.5 (5.8 to 9.1)+7.8 (6.0 to 9.6)+0.4 (0.1 to 0.6)0.4 (0.2 to 0.7)
Albumin level (g/liter)NSNSNS−0.3 (−0.5 to −0.1)−0.4 (−0.6 to −0.2)
Bilirubin level (μmol/liter)+0.7 (0.1 to 1.3)+1.0 (0.3 to 1.7)NS+3.6 (1.1 to 6.1)+3.8 (0.5 to 7.0)NS
γ-GT (units/liter)NS+0.1 (0.0 to 0.1)+0.1 (0.0 to 0.1)NSNS
  • a Thechanges in AUC0-8 shown are associated with unitary increases in the covariate factors. Multivariate analyses showed no significant relationship of alanine transaminase, aspartate transaminase, or alkaline phosphatase and AUC0-8 for any drug.

  • b n, the number of observations included in the model; unless indicated otherwise in the text, observations were dropped from the model because significant covariates were missing.

  • c NS, no significant relationship with AUC0-8 in multivariate model.

  • d Single drug products were used in all participants.

  • e Data in parentheses represent the median (interquartile range) AUC0-8 in milligrams·hour·liter−1.