TABLE 1.

Steady-state pulmonary tissue pharmacokinetic parameters of aerosolized EPAS and SFL itraconazole formulations and orally administered SOL

Itraconazole formulationCmax (μg/g)AUC0 − 24 h (μg · h/g)Tmax (h)Half-life (h)
EPAS25.970.90.57.2
SFL5.328.00.52.9
SOL1.5NDaNDND
  • a ND, not detected (below lower limit of quantification).